\u75db\u98a8\u30fb\u9ad8\u5c3f\u9178\u8840\u75c7\u306f\u751f\u6d3b\u7fd2\u6163\u75c5\u3067\u3042\u308a\uff0c\u98df\u4e8b\u7642\u6cd5\uff0c\u98f2\u9152\u5236\u9650\uff0c\u904b\u52d5\u306a\u3069\u306e\u751f\u6d3b\u6307\u5c0e\u304c\u57fa\u672c\u3068\u306a\u308a\u307e\u3059\uff0e\u9069\u6b63\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u6442\u53d6\uff0c\u30d7\u30ea\u30f3\u4f53\u30fb\u679c\u7cd6\u306e\u904e\u5270\u6442\u53d6\u306e\u56de\u907f\uff0c\u9069\u5207\u306a\u98f2\u6c34\u304c\u52e7\u3081\u3089\u308c\u307e\u3059\uff0e\u8fd1\u5e74\u5c3f\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306e\u907a\u4f1d\u5b50\u5909\u7570\u304c\u75c5\u614b\u767a\u75c7\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u304c\uff0c\u3044\u305a\u308c\u306b\u305b\u3088\u751f\u6d3b\u6307\u5c0e\u306e\u9806\u5b88\u306f\u91cd\u8981\u3067\u3059\uff0e\u30d3\u30fc\u30eb\u306f\u30d7\u30ea\u30f3\u4f53\u542b\u6709\u91cf\u304c\u591a\u304f\uff0c\u84b8\u7559\u9152\u3084\u30ef\u30a4\u30f3\u3088\u308a\u3082\u8840\u6e05\u5c3f\u9178\u5024\u3092\u4e0a\u6607\u3055\u305b\u308b\u305f\u3081\uff0c\u63a7\u3048\u308b\u306e\u304c\u671b\u307e\u3057\u3044\u3067\u3059\uff0e<\/p>\n\n\n\n
\u85ac\u7269\u6cbb\u7642\u306e\u9069\u5fdc\u306b\u95a2\u3057\u3066\u306f\u300c\u9ad8\u5c3f\u9178\u8840\u75c7\u30fb\u75db\u98a8\u306e\u6cbb\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 \u7b2c3\u7248\u300d\u306e\u6cbb\u7642\u6307\u91dd\u304c\u53c2\u8003\u306b\u306a\u308a\u307e\u3059\uff0e\u75db\u98a8\u3092\u304f\u308a\u8fd4\u3059\u60a3\u8005\u3055\u3093\u306f\u85ac\u7269\u6cbb\u7642\u306e\u9069\u5fdc\u3068\u306a\u308a\uff0c\u8840\u6e05\u5c3f\u9178\u5024\u30926.0 mg\/dL\u4ee5\u4e0b\u306b\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3057\u307e\u3059\uff0e\u307e\u305f\uff0c\u75db\u98a8\u767a\u4f5c\u3092\u8a98\u767a\u3055\u305b\u306a\u3044\u305f\u3081\u306b\uff0c\u5c3f\u9178\u964d\u4e0b\u85ac\u306f\u6700\u5c0f\u91cf\u304b\u3089\u958b\u59cb\u3057\uff0c\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u30b3\u30eb\u30d2\u30c1\u30f3\u30ab\u30d0\u30fc\u3092\u4f75\u7528\u3057\u307e\u3059\uff0e\u7121\u75c7\u5019\u6027\u9ad8\u5c3f\u9178\u8840\u75c7\u3078\u306e\u85ac\u7269\u6cbb\u7642\u958b\u59cb\u306f\u8840\u6e05\u5c3f\u9178\u50248.0 mg\/dL\u4ee5\u4e0a\u3092\u4e00\u5fdc\u306e\u76ee\u5b89\u306b\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n
\u9ad8\u5c3f\u9178\u8840\u75c7\u306e\u75c5\u578b\u5206\u985e\u306f\uff0c\u814e\u306b\u304a\u3051\u308b\u5c3f\u9178\u306e\u6392\u6cc4\u52b9\u7387\u304c\u4f4e\u4e0b\u3057\u305f\u300c\u5c3f\u9178\u6392\u6cc4\u4f4e\u4e0b\u578b\u300d\uff0c\u814e\u306b\u5bfe\u3059\u308b\u5c3f\u9178\u8ca0\u8377\u304c\u5897\u5927\u3057\uff0c\u8840\u6e05\u5c3f\u9178\u5024\u306e\u4e0a\u6607\u3092\u304d\u305f\u3059\u300c\u814e\u8ca0\u8377\u578b\u300d\uff0c\u305d\u306e\u4e21\u8005\u3092\u8981\u56e0\u3068\u3059\u308b\u300c\u6df7\u5408\u578b\u300d\u306b\u5927\u5225\u3055\u308c\u307e\u3059\uff0e\u3055\u3089\u306b\u814e\u8ca0\u8377\u578b\u306f\u5c3f\u9178\u306e\u7523\u751f\u91cf\u304c\u5897\u52a0\u3059\u308b\u300c\u5c3f\u9178\u7523\u751f\u904e\u5270\u578b\u300d\u3068\u8178\u7ba1\u304b\u3089\u306e\u5c3f\u9178\u6392\u6cc4\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u306b\u814e\u304b\u3089\u306e\u5c3f\u9178\u6392\u6cc4\u304c\u5897\u52a0\u3059\u308b\u300c\u814e\u5916\u6392\u6cc4\u4f4e\u4e0b\u578b\u300d\u306b\u5206\u3051\u3089\u308c\u307e\u3059\uff0e\u75c5\u578b\u5206\u985e\u306b\u5fdc\u3058\u3066\uff0c\u5c3f\u9178\u6392\u6cc4\u4f4e\u4e0b\u578b\u306b\u306f\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u3092\u6295\u4e0e\u3057\uff0c\u5c3f\u9178\u7523\u751f\u904e\u5270\u578b\u306b\u306f\u5c3f\u9178\u751f\u6210\u6291\u5236\u85ac\u3092\u6295\u4e0e\u3059\u308b\u306e\u304c\u539f\u5247\u3067\u3059\u304c\uff0c\u5408\u4f75\u75c7\u306a\u3069\u8003\u616e\u3057\u3066\u81e8\u6a5f\u5fdc\u5909\u306b\u6295\u4e0e\u85ac\u3092\u691c\u8a0e\u3059\u3079\u304d\u3067\u3059\uff0e<\/p>\n\n\n\n
\u6700\u8fd1\uff0c\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u3067\u65b0\u3057\u3044\u85ac\u3067\u3042\u308b\u30c9\u30c1\u30cc\u30e9\u30c9\u304c\u4e0a\u5e02\u3055\u308c\uff0c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u307e\u3059\uff0e\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3067\u306e\u5c3f\u9178\u306e\u518d\u5438\u53ce\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u5c3f\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306eURAT1\u3092\u7279\u7570\u7684\u306b\u963b\u5bb3\u3057\uff0c\u5c3f\u7d30\u7ba1\u3084\u8178\u7ba1\u3067\u5c3f\u9178\u306e\u5438\u53ce\u306b\u50cd\u304f\u5c3f\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3067\u3042\u308bABCG2\u306f\u307b\u3068\u3093\u3069\u963b\u5bb3\u3057\u306a\u3044\u305f\u3081\uff0c\u3088\u308a\u5f37\u529b\u306a\u5c3f\u9178\u964d\u4e0b\u4f5c\u7528\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\uff0e<\/p>\n\n\n\n
\u85ac\u306e\u57fa\u790e\u77e5\u8b58<\/p>\n\n\n\n
1 \u5c3f\u9178\u751f\u6210\u6291\u5236\u85ac<\/p>\n\n\n\n
\u30ad\u30b5\u30f3\u30c1\u30f3\u9178\u5316\u9084\u5143\u9175\u7d20\uff08XOR\uff09\u963b\u5bb3\u85ac\u3068\u3057\u3066\u4ee5\u4e0b\u306e3\u3064\u304c\u4f7f\u7528\u3067\u304d\u307e\u3059\uff0e<\/p>\n\n\n\n
\u65b0\u898f\u306e2\u85ac\u5264\u306f\u80c6\u6c41\u304b\u3089\u306e\u6392\u6cc4\u7d4c\u8def\u3092\u6709\u3059\u308b\u305f\u3081\uff0c\u4e2d\u7b49\u5ea6\u307e\u3067\u306e\u814e\u6a5f\u80fd\u4f4e\u4e0b\u60a3\u8005\u306b\u5bfe\u3057\u3066\u6e1b\u91cf\u306e\u5fc5\u8981\u304c\u3042\u308a\u307e\u305b\u3093\uff0e\u3055\u3089\u306b\u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u85ac\u5264\u76f8\u4e92\u4f5c\u7528\u304c\u5c11\u306a\u304f\u4f7f\u7528\u3057\u3084\u3059\u3044\u3067\u3059\uff0e\u305f\u3060\u3057\uff0c\u30e1\u30eb\u30ab\u30d7\u30c8\u30d7\u30ea\u30f3\u6c34\u548c\u7269\u307e\u305f\u306f\u30a2\u30b6\u30c1\u30aa\u30d7\u30ea\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u3044\u305a\u308c\u306eXOR\u963b\u5bb3\u85ac\u306b\u3082\u5171\u901a\u3057\u3066\u3044\u308b\u306e\u3067\u6ce8\u610f\u3059\u3079\u304d\u3067\u3059\uff0e<\/p>\n\n\n\n
1\uff09 \u30a2\u30ed\u30d7\u30ea\u30ce\u30fc\u30eb<\/p>\n\n\n\n
1969\u5e74\u306b\u767a\u58f2\u3055\u308c\u9577\u304f\u4f7f\u7528\u3055\u308c\u3066\u304d\u307e\u3057\u305f\uff0e\u30d7\u30ea\u30f3\u4f53\u9aa8\u683c\u3092\u6709\u3057\uff0cXOR\u306e\u6d3b\u6027\u4e2d\u5fc3\u306b\u7d50\u5408\u3057\uff0c\u53cd\u5fdc\u3092\u53d7\u3051\u30aa\u30ad\u30b7\u30d7\u30ea\u30ce\u30fc\u30eb\u3092\u751f\u6210\u3057\u307e\u3059\uff0e\u30aa\u30ad\u30b7\u30d7\u30ea\u30ce\u30fc\u30eb\u306e\u4e00\u90e8\u304cXOR\u306b\u5f31\u3044\u5171\u6709\u7d50\u5408\u3067\u53cd\u5fdc\u4e2d\u5fc3\u306b\u7d50\u5408\u3057\uff0cXOR\u6d3b\u6027\u3092\u963b\u5bb3\u3057\u5c3f\u9178\u751f\u6210\u3092\u963b\u5bb3\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n
\u983b\u5ea6\u306f\u6c7a\u3057\u3066\u591a\u304f\u306f\u3042\u308a\u307e\u305b\u3093\u304c\uff0c\u526f\u4f5c\u7528\u3068\u3057\u3066\u4e2d\u6bd2\u6027\u8868\u76ae\u58ca\u6b7b\u75c7\uff0cStevens-Johnson\u75c7\u5019\u7fa4\u3068\u3044\u3063\u305f\u91cd\u7be4\u306a\u5408\u4f75\u75c7\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059\uff0e\u91cd\u75c7\u85ac\u75b9\u306fHLA-B\uff0a5801\u907a\u4f1d\u5b50\u4fdd\u6709\u8005\u306b\u9ad8\u7387\u306b\u751f\u305a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u304c\uff0c\u65e5\u672c\u4eba\u306e\u4fdd\u6709\u7387\u306f1.2\uff05\u3068\u4f4e\u7387\u3067\u3059\uff0e\u814e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u4f34\u3044\u30aa\u30ad\u30b7\u30d7\u30ea\u30ce\u30fc\u30eb\u306e\u8840\u4e2d\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u305f\u3081\uff0c\u814e\u6a5f\u80fd\u306b\u5fdc\u3058\u3066\u6295\u4e0e\u91cf\u3092\u8abf\u7bc0\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\uff0e\u307e\u305f\uff0c\u30b7\u30af\u30ed\u30b9\u30dd\u30ea\u30f3\uff0c\u30c6\u30aa\u30d5\u30a3\u30ea\u30f3\u3084\u30ef\u30eb\u30d5\u30a1\u30ea\u30f3\u306a\u3069\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\uff0e<\/p>\n\n\n\n
2\uff09 \u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8<\/p>\n\n\n\n
2011\u5e74\u306b\u65e5\u672c\u3067\u767a\u58f2\u3055\u308c\u307e\u3057\u305f\uff0eXOR\u306e\u6d3b\u6027\u4e2d\u5fc3\u4ed8\u8fd1\u306b\u7d50\u5408\u3057\uff0c\u57fa\u8cea\u3068\u306a\u308b\u30ad\u30b5\u30f3\u30c1\u30f3\u306e\u7d50\u5408\u3092\u30d6\u30ed\u30c3\u30af\u3057\uff0c\u9175\u7d20\u6d3b\u6027\u3092\u4f4e\u4e0b\u3055\u305b\u3066\u5c3f\u9178\u751f\u6210\u3092\u963b\u5bb3\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n
3\uff09 \u30c8\u30d4\u30ed\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8<\/p>\n\n\n\n
2013\u5e74\u306b\u65e5\u672c\u3067\u767a\u58f2\u3055\u308c\u307e\u3057\u305f\uff0e\u85ac\u7269\u81ea\u8eab\u304c\u9175\u7d20\u306b\u3088\u308a\u6c34\u9178\u5316\u3055\u308c\u306a\u304c\u3089\u4e2d\u9593\u4f53\u3092\u7dad\u6301\u3057\uff0c\u3055\u3089\u306bXOR\u306e\u9175\u7d20\u6d3b\u6027\u4e2d\u5fc3\u3092\u57cb\u3081\u5c3d\u304f\u3059\u3088\u3046\u306a\u5f62\u614b\u3067\u7d50\u5408\u3057\uff0c\u57fa\u8cea\u3092\u30d6\u30ed\u30c3\u30af\u3059\u308b\u3053\u3068\u3067\u5c3f\u9178\u751f\u6210\u3092\u963b\u5bb3\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n
2 \u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac<\/p>\n\n\n\n
URAT1\u963b\u5bb3\u85ac\u306e\u30d9\u30f3\u30ba\u30d6\u30ed\u30de\u30ed\u30f3\u304c1978\u5e74\u304b\u3089\u4f7f\u7528\u3055\u308c\u3066\u3044\u307e\u3059\uff0eURAT1\u306f\u4e3b\u306b\u814e\u5c3f\u7d30\u7ba1\u306b\u5206\u5e03\u3057\uff0c\u5c3f\u9178\u518d\u5438\u53ce\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u5c3f\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3067\u3059\uff0e\u814e\u6a5f\u80fd\u4f4e\u4e0b\u3067\u306f\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u306e\u52b9\u679c\u306f\u6e1b\u5f31\u3059\u308b\u3053\u3068\u304c\u60f3\u5b9a\u3055\u308c\u307e\u3059\u304c\uff0c\u30d9\u30f3\u30ba\u30d6\u30ed\u30de\u30ed\u30f3\u306e\u4f5c\u7528\u306f\u5f37\u529b\u3067\uff0cStage 3\u306eCKD\u60a3\u8005\u306b\u306f\u5e38\u7528\u91cf\u3067\u3082\u5341\u5206\u306b\u8840\u6e05\u5c3f\u9178\u5024\u306e\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306f\u53ef\u80fd\u3067\uff0cStage 4\u306b\u304a\u3044\u3066\u3082\u6295\u4e0e\u91cf\u3092\u5897\u91cf\u3059\u308b\u3053\u3068\u3067\u8840\u6e05\u5c3f\u9178\u5024\u306e\u4f4e\u4e0b\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\uff0e<\/p>\n\n\n\n
\u9ad8\u5c3f\u9178\u8840\u75c7\u306f\u5c3f\u9178\u7d50\u77f3\u306e\u307f\u306a\u3089\u305a\u5c3f\u8def\u7d50\u77f3\u5168\u822c\u306e\u5371\u967a\u56e0\u5b50\u3067\u3042\u308a\uff0c\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u4f7f\u7528\u6642\u306f\u5c3f\u8def\u7d50\u77f3\u4e88\u9632\u306e\u305f\u3081\u306e\u5c3f\u8def\u7ba1\u7406\u3092\u5341\u5206\u884c\u3046\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\uff0e\u6c34\u5206\u3092\u5341\u5206\u306b\u6442\u53d6\u3057\u3066\u5c3f\u91cf\u5897\u52a0\u3092\u4fdd\u3061\uff0c\u9178\u6027\u5c3f\u3067\u306f\u5c3f\u8def\u7d50\u77f3\u304c\u3067\u304d\u3084\u3059\u3044\u305f\u3081\uff0c\u30af\u30a8\u30f3\u9178\u30ab\u30ea\u30a6\u30e0\u30fb\u30af\u30a8\u30f3\u9178\u30ca\u30c8\u30ea\u30a6\u30e0\u306e\u6295\u4e0e\u3067\u5c3f\u3092\u30a2\u30eb\u30ab\u30ea\u5316\u3055\u305b\u307e\u3059\uff0e\u305f\u3060\u3057\u814e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u3042\u308b\u3068\u304d\u306f\u8840\u6e05\u30ab\u30ea\u30a6\u30e0\u5024\u3092\u4e0a\u6607\u3055\u305b\u306a\u3044\u3088\u3046\u306b\u6ce8\u610f\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n
\u30d9\u30f3\u30ba\u30d6\u30ed\u30de\u30ed\u30f3\u306f\u809d\u969c\u5bb3\u30ea\u30b9\u30af\u304c\u61f8\u5ff5\u3055\u308c\u3066\u304a\u308a\uff0c\u305d\u306e\u70b9\u3092\u514b\u670d\u3059\u308b\u85ac\u5264\u3068\u3057\u3066\u30c9\u30c1\u30cc\u30e9\u30c9\u304c\u65e5\u672c\u3067\u958b\u767a\u3055\u308c\u307e\u3057\u305f\uff0e\u30c9\u30c1\u30cc\u30e9\u30c9\u306f\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u3067\u306e\u5c3f\u9178\u306e\u518d\u5438\u53ce\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u5c3f\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u306eURAT1\u3092\u7279\u7570\u7684\u306b\u963b\u5bb3\u3057\uff0c\u5c3f\u7d30\u7ba1\u3084\u8178\u7ba1\u3067\u5c3f\u9178\u306e\u5438\u53ce\u306b\u50cd\u304f\u5c3f\u9178\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\u3067\u3042\u308bABCG2\u306f\u307b\u3068\u3093\u3069\u963b\u5bb3\u3057\u307e\u305b\u3093\uff0e\u30c9\u30c1\u30cc\u30e9\u30c9\u306f\u65e2\u5b58\u306e\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u306b\u6bd4\u3079\uff0cURAT1\u963b\u5bb3\u304c\u5f37\u304f\u304b\u3064URAT1\u9078\u629e\u6027\u304c\u9ad8\u3044\u300c\u9078\u629e\u7684\u5c3f\u9178\u518d\u5438\u53ce\u963b\u5bb3\u85ac\u300d\u3067\u3042\u308a\uff0c\u8178\u7ba1\u306b\u304a\u3044\u3066ABCG2\u3092\u963b\u5bb3\u3057\u306a\u3044\u305f\u3081\u814e\u81d3\u3078\u306e\u5c3f\u9178\u8ca0\u8377\u3092\u56de\u907f\u3059\u308b\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u3068\u8a00\u3048\u307e\u3059\uff0e\u7528\u91cf\u53cd\u5fdc\u691c\u8a3c\u8a66\u9a13\u3067\uff0c\u6295\u4e0e\u7d42\u4e86\u6642\u306e\u8840\u6e05\u5c3f\u9178\u50246.0mg\/dL\u4ee5\u4e0b\u306e\u9054\u6210\u7387\u306f0.5mg\u306723.1%\uff0c1mg\u306765.9%\uff0c2mg\u306774.4%\uff0c4mg\u3067100%\u3068\u3053\u308c\u307e\u3067\u306e\u85ac\u5264\u306b\u6bd4\u3079\u3066\u9855\u8457\u306a\u5c3f\u9178\u964d\u4e0b\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\uff0e\u80a5\u6e80\u3092\u4f34\u3046\u9ad8\u5c3f\u9178\u8840\u75c7\u3067\u306f\u5c3f\u9178\u6392\u6cc4\u4f4e\u4e0b\u578b\u304c\u591a\u304f\uff0c\u30c9\u30c1\u30cc\u30e9\u30c9\u306f\u4eca\u5f8c\u7a4d\u6975\u7684\u306b\u4f7f\u7528\u3057\u3066\u3088\u3044\u85ac\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff0e<\/p>\n\n\n\n
3 \u5c3f\u9178\u5206\u89e3\u9175\u7d20\u85ac\uff08\u30e9\u30b9\u30d6\u30ea\u30ab\u30fc\u30bc\uff09<\/p>\n\n\n\n
\u816b\u760d\u5d29\u58ca\u75c7\u5019\u7fa4\uff08TLS\uff09\u306b\u306e\u307f\u9069\u5fdc\u304c\u3042\u308b\u907a\u4f1d\u5b50\u7d44\u63db\u3048\u578b\u306e\u5c3f\u9178\u30aa\u30ad\u30b7\u30c0\u30fc\u30bc\uff08\u30a6\u30ea\u30ab\u30fc\u30bc\uff0c\u30a6\u30ea\u30b1\u30fc\u30b9\u3068\u3082\u3044\u3046\uff09\u3067\u3059\uff0eTLS\u3068\u306f\u816b\u760d\u7d30\u80de\u3092\u85ac\u7269\u7642\u6cd5\u306a\u3069\u3067\u6025\u6fc0\u306b\u7834\u58ca\u3059\u308b\u969b\u306b\uff0c\u7d30\u80de\u5185\u6210\u5206\u306e\u6025\u901f\u306a\u653e\u51fa\u306b\u3088\u308a\uff0c\u9ad8\u5c3f\u9178\u8840\u75c7\uff0c\u9ad8\u30ab\u30ea\u30a6\u30e0\u8840\u75c7\uff0c\u9ad8\u30ea\u30f3\u8840\u75c7\u304c\u6025\u901f\u306b\u751f\u3058\u308b\u75c5\u614b\u3067\u3059\uff0e\u30e9\u30b9\u30d6\u30ea\u30ab\u30fc\u30bc\u306f\u5c3f\u9178\u3092\u814e\u81d3\u304b\u3089\u6392\u51fa\u3055\u308c\u3084\u3059\u3044\u30a2\u30e9\u30f3\u30c8\u30a4\u30f3\u306b\u5206\u89e3\u3059\u308b\u3053\u3068\u3067\u8840\u6e05\u5c3f\u9178\u5024\u3092\u3059\u307f\u3084\u304b\u306b\u4f4e\u4e0b\u3055\u305b\u307e\u3059\uff0e\u6ce8\u610f\u70b9\u3068\u3057\u3066\uff0c\u30e9\u30b9\u30d6\u30ea\u30ab\u30fc\u30bc\u6295\u4e0e\u306e\u7d041\u5272\u3067\u6297\u4f53\u7523\u751f\u304c\u8a8d\u3081\u3089\u308c\uff0c\u518d\u6295\u4e0e\u306e\u969b\u306b\u30a2\u30ca\u30d5\u30a3\u30e9\u30ad\u30b7\u30fc\u304c\u751f\u3058\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff0e<\/p>\n\n\n\n
\u75db\u98a8\u767a\u4f5c\u6642\u306e\u8003\u3048\u65b9<\/p>\n\n\n\n
\u75c7\u4f8b1<\/p>\n\n\n\n
60\u6b73\u7537\u6027\uff0e1\u30ab\u6708\u524d\u304b\u3089\u5de6\u8098\uff0c\u53f3\u7b2c1\u8db3\u8dbe\u306e\u75db\u307f\u304c\u5f37\u304f\u306a\u308a\uff0c\u5185\u79d1\u5916\u6765\u3092\u53d7\u8a3a\u3057\u307e\u3057\u305f\uff0e\u81e8\u5e8a\u7684\u306b\u75db\u98a8\u767a\u4f5c\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\uff0e<\/p>\n\n\n\n
\u8eab\u9577175 cm\uff0c\u4f53\u91cd78 kg\uff0e\u8840\u5727160\/95 mmHg\uff0c\u8108\u62cd80\/\u5206\uff0c\u6574\uff0e<\/p>\n\n\n\n
\u8840\u6db2\u691c\u67fb\uff1aAlb 3.9 g\/dL\uff0cBUN 15.0 mg\/dL\uff0cCr 1.10 mg\/dL\uff0cUA 8.7 mg\/dL\uff0cHbA1c 6.1\uff05\uff0cCRP 2.5 mg\/dL\uff0e<\/p>\n\n\n\n
\u5c3f\u691c\u67fb\uff1aCr 250 mg\/dL\uff0c\u5c3f\u917850 mg\/dL\uff0e<\/p>\n\n\n\n
\u75db\u98a8\u767a\u4f5c\u304a\u3088\u3073\u9ad8\u5c3f\u9178\u8840\u75c7\u306b\u5bfe\u3057\u3066\u3069\u306e\u3088\u3046\u306b\u5bfe\u5fdc\u3059\u3079\u304d\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n\n\n\n
\u75db\u98a8\u767a\u4f5c\u6642\u306b\u306f\uff0c\u77ed\u6642\u9593\u4f5c\u7528\u578b\u306e\u5f37\u529b\u306aNSAIDs\u306e\u5341\u5206\u91cf\u306e\u6295\u4e0e\u306b\u3088\u308a\u3067\u304d\u308b\u3060\u3051\u3059\u307f\u3084\u304b\u306b\u6d88\u892a\u3055\u305b\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\uff0e\u8840\u6e05\u5c3f\u9178\u5024\u306e\u6025\u6fc0\u306a\u5909\u52d5\u304c\u75db\u98a8\u767a\u4f5c\u3092\u8a98\u767a\u3059\u308b\u305f\u3081\uff0c\u75db\u98a8\u767a\u4f5c\u304c\u6cbb\u307e\u308b\u307e\u3067\u5c3f\u9178\u964d\u4e0b\u85ac\u306e\u958b\u59cb\u3092\u5f85\u3064\u3079\u304d\u3067\u3059\uff0e\u75db\u98a8\u767a\u4f5c\u304c\u6cbb\u307e\u3063\u305f\u3089\uff0c\u5c3f\u9178\u964d\u4e0b\u85ac\u306e\u958b\u59cb\u3092\u691c\u8a0e\u3057\u307e\u3059\uff0e\u306a\u304a\uff0c\u5c3f\u9178\u964d\u4e0b\u85ac\u3092\u670d\u7528\u4e2d\u306b\u75db\u98a8\u95a2\u7bc0\u708e\u3092\u8d77\u3053\u3057\u305f\u60a3\u8005\u3067\u306f\uff0c\u5c3f\u9178\u964d\u4e0b\u85ac\u3092\u4e2d\u6b62\u3059\u308b\u3053\u3068\u306a\u304f\uff0c\u6295\u4e0e\u3092\u7d99\u7d9a\u3057\u3066NSAIDs\u3092\u8ffd\u52a0\u3057\u307e\u3059\u3002<\/p>\n\n\n\n
\u5c3f\u304b\u3089\u306egCr\u3042\u305f\u308a\u306e\u5c3f\u9178\u6392\u6cc4\u7387\u3092\u8a08\u7b97\u3059\u308b\u306850\/250\uff1d0.2 g\/gCr\u3068\u306a\u308a\u307e\u3059\uff0e\u7c21\u4fbf\u306b\u306f\u968f\u6642\u5c3f\u306e0.5 g\/gCr\u4ee5\u4e0a\u3067\u3042\u308c\u3070\u5c3f\u9178\u7523\u751f\u904e\u5270\u578b\uff0c0.5 g\/gCr\u4ee5\u4e0b\u3067\u3042\u308c\u3070\u5c3f\u9178\u6392\u6cc4\u4f4e\u4e0b\u578b\u3068\u5206\u985e\u3055\u308c\u308b\u305f\u3081\uff0c\u672c\u4f8b\u3067\u306f\u5c3f\u9178\u6392\u6cc4\u4f4e\u4e0b\u578b\u3068\u306a\u308a\u307e\u3059\uff0e\u5c3f\u4e2d\u5c3f\u9178\u6fc3\u5ea6\u304c50 mg\/dL\u4ee5\u4e0a\u3067\u3042\u308c\u3070\u98f2\u6c34\u6307\u5c0e\u3092\u5f37\u5316\u3057\u3066\u5e0c\u91c8\u5c3f\u306b\u3055\u305b\u308b\u3053\u3068\u3082\u63a8\u5968\u3055\u308c\u307e\u3059\uff0e\u5c3f\u9178\u6392\u6cc4\u4f4e\u4e0b\u578b\u3067\u306f\u7406\u8ad6\u7684\u306b\u306f\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u3092\u6295\u4e0e\u3057\u307e\u3059\u304c\uff0c\u30d5\u30a7\u30d6\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\uff0c\u30c8\u30d4\u30ed\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\u3092\u4f7f\u3046\u3053\u3068\u3082\u53ef\u80fd\u3067\u3059\uff0e\u5c3f\u9178\u6392\u6cc4\u4fc3\u9032\u85ac\u3067\u306f\u8fd1\u5e74\u958b\u767a\u3055\u308c\u305f\u9078\u629e\u7684\u5c3f\u9178\u518d\u5438\u53ce\u963b\u5bb3\u85ac\u3067\u3042\u308b\u30c9\u30c1\u30cc\u30e9\u30c9\u304c\u809d\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u3082\u9ad8\u304f\u306a\u304f\u4f7f\u3044\u3084\u3059\u3044\u3067\u3059\uff0e\u4ee5\u524d\u306e\u5c3f\u9178\u6392\u6cc4\u85ac\u3067\u3042\u308b\u30d9\u30f3\u30ba\u30d6\u30ed\u30de\u30ed\u30f3\u3092\u6295\u4e0e\u3059\u308b\u5834\u5408\u306f\uff0c\u5287\u75c7\u809d\u708e\u306a\u3069\u306e\u91cd\u7be4\u306a\u809d\u969c\u5bb3\u304c\u4e3b\u306b\u958b\u59cb6\u30ab\u6708\u4ee5\u5185\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u305f\u3081\u306b\u5c11\u306a\u304f\u3068\u30826\u30ab\u6708\u9593\u306f\u5fc5\u305a\u5b9a\u671f\u7684\u306b\u809d\u6a5f\u80fd\u691c\u67fb\u3092\u884c\u3044\u307e\u3059\uff0e\u6025\u6fc0\u306a\u8840\u6e05\u5c3f\u9178\u5024\u306e\u4f4e\u4e0b\u306f\u75db\u98a8\u767a\u4f5c\u3092\u8a98\u767a\u3059\u308b\u305f\u3081\u3067\u304d\u308b\u3060\u3051\u5c11\u306a\u3044\u6295\u4e0e\u91cf\u304b\u3089\u958b\u59cb\u3059\u308b\u3053\u3068\u304c\u671b\u307e\u3057\u3044\u3067\u3059\uff0e\u6295\u4e0e\u958b\u59cb2\u9031\u9593\u4ee5\u964d\u306b\u6295\u4e0e\u91cf\u306e\u5897\u91cf\u3092\u691c\u8a0e\u3057\u307e\u3059\uff0e\u75db\u98a8\u767a\u4f5c\u304c\u983b\u767a\u3057\u3066\u3044\u308b\u5834\u5408\uff0c\u30b3\u30eb\u30d2\u30c1\u30f30.5\uff5e1.0 mg\/\u65e5\u3092\u5c3f\u9178\u964d\u4e0b\u85ac\u958b\u59cb\u5f8c3\uff5e6\u30ab\u6708\u9593\u4f75\u7528\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\uff08\u30b3\u30eb\u30d2\u30c1\u30f3\u30ab\u30d0\u30fc\uff09\uff0e<\/p>\n\n\n\n
\u25cf\u51e6\u65b9\u4f8b<\/p>\n\n\n\n
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\u30c8\u30d4\u30ed\u30ad\u30bd\u30b9\u30bf\u30c3\u30c8\uff08\u30a6\u30ea\u30a2\u30c7\u30c3\u30af\u00ae\uff091\u56de20 mg 1\u65e52\u56de\uff08\u671d\u5915\u98df\u5f8c\uff09<\/p>\n\n\n\n
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